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35 μM; Table four). This result indicates that a number of modifications may be integrated to the Api-137 sequence without leading to a lessen during the exercise on the molecule. To our know-how, This can be the initially example of an Api-137 derivative which includes multiple modifications within the C-terminus which have been tolerated and do

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We've completed framework-guided modifications of antimicrobial peptide apidaecin to test if its derivatives would tolerate substitutions that change the interaction on the peptide with ribosome—tRNA—RF and/or get proteolytic balance. We have found a number of amino acid substitutions and modifications that maintain the antibacterial activity o

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